mt3

Molecular Toxicology and Cell and Tissue Culture Technology [empty tree]

.\mt3 .\AIMMS .\Chemistry and Pharmaceutical Sciences .\Faculty of Science

Molly Malones Amsterdam, 2025 Anja and Paul, Innsbruck July 2025

Molecular Toxicology is specialised in developing human in vitro (non-animal) based strategies for the understanding of the molecular mechanisms of chemical-induced toxicity in order to better predict chemical safety in humans. The laboratory is specialised in human cell culture, metabolism, toxicity determination and omic analysis. In vitro models include human primary cells, human cell lines and induced human Pluripotent Stem Cell derived cells.

Paul Jennings [ORCID] is a specialist in human cell culture, cell biology, renal phyisology and molecular toxicology and leads Molecular Toxicology.
Anja Wilmes [ORCID] is a specialist in iPSCs, differentiation, cancer biology, co-cultures and organ on a chip technology and leads Cell and Tissue Culture Technology.

What is toxicology ? Toxicology is the study of poisons and their effects on cellular systems. However, everything is poisionous, it is the dose that makes something a poison. [read more]

Address:
Division of Molecular Toxicology,
Department of Chemistry and Pharmaceutical Sciences,
Amsterdam Institute for Molecules, Medicines and Systems,
Vrije Universiteit Amsterdam,
De Boelelaan, 1108,
1081 HZ Amsterdam,
The Netherlands.
Floor 3, O|2 building.
[ Google map link ]
email p.jennings@vu.nl, e.v.langemeijer@vu.nl

Announcements

July 2025 Vidya and Cormac defend their PhD thesis.Yipee
June 2025: Lenya strikes again and wins the best PhD presentation at the NVT 2025. Congrats Lenya ! 🎈

mt3 team

Senior Scientific Staff

Anja's Team

Prof. Dr. Paul Jennings
Dr. Anja Wilmes (Assistant Prof.)
Dr. Chris Vos (Assosc. Prof)
Dr. Ellen Langemeijer (Project manager)

mt3 teks

Daniel Da Costa Pereira
Michaela Venter

mt3 - PhD alumni

Dr. Cormac Murphy - All wrapped up.
Dr. Vidya Chandrasekaran - Renal redifined.
Dr. Giada Carta - Detection And Characterisation Of Chemical Induced Mitochondrial Perturbations utilising human in vitro models
Dr. Liliana Capinha - Application of new approach methodologies in molecular toxicology: A case study on metabolism and cellular stress responses from glutathione conjugation products of trichloroethylene
Dr. Sandra Ortega Ugalde A new target for an old enemy
Dr. Angelina Huseinovic Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis
Dr. Stefan Dekker Characterization of biotransformation enzymes involved in Adverse Drug Reactions.

Dr. Thaís Silva Pinto
Aya Hinawi
Lenya de Brouwer
Olivia Klatt
Tamara Meijer

Paul's Team
Dr. Vidya Chandrasekaran
Dr. Tugce Boran
David Heiler
Victoria Pozo Garcia

mt3 publications

All Publications PubMed

Recent publications

/ The problem with pericellular hypoxia in mammalian cell culture.
/ A Self-Reinforcing Pathway Linking PIEZO1 and 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropionate, a Renal Retention Solute, with CKD Progression.
/ Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models
/ Human and rat renal proximal tubule in vitro models for ADME applications
/ Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models.
/ Differentiation and Subculturing of Renal Proximal Tubular-like Cells Derived from Human iPSC
/ Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures
/ Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

Video Section

Highlights

(hover over for details)

Vidyas PhD defense 2025 July Amsterdam

Congratulations Lenya for winning the best poster award at the 2025 AIMMS festival

ULLA Summer School, June 2019, Liliana receives the best pitch for the kinetics of parabens

Shalenie den Braver accepting her certificate for the Joep van den Berken 2019 thesis award from Prof. dr. Henk van Loveren at the NVT annual meeting in Ede June 2019.

Robin Coosen accepting the 2019 Bachelor Pharmaceutical Sciences poster award from Chris Vos.

Congratulations to Sandra and Vidya for their AIMMS talk and AIMMS poster prize at the AIMMS day 18th April, 2019.

Projects

The group is a partner in several EU level and national projects. The images and links below capture some of them.

Chiasma 2024: Accessible Innovative Methods for the Safety & Sustainability Assessment of Chemicals & Materials. CHIASMA has received funding from the European Union s Horizon Europe Research and Innovation programme under grant agreement No. 101137613.
RISKHUNT3R EU Horizon 2020 Grant No 964537. Hunting for chemical risks using NAMs!
VHP4Safety. NWA-funded Virtual Human Platform 4 Safety project. started June 2021.
Matrigel replacement project.funded by SET

Its the Halk.

mt3 Duckery

mt3 logo explained (drawn by the the talented Sam McCabe).

The logo symbolises the ability to model from biological data (the blue liver shaped centre) - in order to expand / fly to new heights of knowledge. The logo also represents the aquatic based habitat of Amsterdam.

We hope you don't think we are quackers.