Home Research | Biotransformation, bioactivation and biocatalysis

Dr. Jelle Reinen

Position: Post-doc

Jelle_Reinen

In December 2004, Jelle Reinen started his PhD research within the Division of Molecular Toxicology at the Vrije Universiteit, under supervision of Prof. Dr. N.P.E. Vermeulen, where he studied the role of biotransformation in the estrogenicity of xenobiotics. Besides studying the effects of endocrine disrupting chemicals (EDCs), both during his PhD project and later on as a postdoctoral fellow (since 2009), Jelle has been involved in the evaluation of the applicability of novel mutants of bacterial cytochrome P450 BM3 for large scale production of drug metabolites. This project was performed in close collaboration with Vertex Pharmaceuticals and from January 2009 until June 2009 part of this research project has been performed at the department of Drug Innovation at Vertex Pharmaceuticals (San Diego, CA, USA). Currently, his research focuses on the efficient screening of P450 BM3 mutant libraries for their metabolic activity and diversity towards drug-like molecules and the efficient application of P450 BM3 mutants as biocatalysts for large scale production of drug metabolites.

Room: P2.75B
Tel: +31 20 5987593
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