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Publications

Please use the search engine below to find the publications of the Division of Molecular Toxicology. You can search on author, research field or year. You can also make a combination. If you want to see all publications by Moltox, check the box 'All Publications';and then click on the button 'Search'. (Note this works only up until 2016, for the time being).

All Publications


2018


Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens. Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P. Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018. PMID: 30559759 [PubMed] Free PMC Article

Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole. Dekker SJ, Dohmen F, Vermeulen NPE, Commandeur JNM. Br J Pharmacol. 2018 Nov 17. doi: 10.1111/bph.14548. [Epub ahead of print] PMID: 30447161 [PubMed - as supplied by publisher]

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases. Zgheib E, Limonciel A, Jiang X, Wilmes A, Wink S, van de Water B, Kopp-Schneider A, Bois FY, Jennings P. Front Genet. 2018 Oct 2;9:429. doi: 10.3389/fgene.2018.00429. eCollection 2018. PMID: 30333853 [PubMed] Free PMC Article

Differentiation of human iPSCs into functional podocytes. Rauch C, Feifel E, Kern G, Murphy C, Meier F, Parson W, Beilmann M, Jennings P, Gstraunthaler G, Wilmes A. PLoS One. 2018 Sep 17;13(9):e0203869. doi: 10.1371/journal.pone.0203869. eCollection 2018. PMID: 30222766 [PubMed - in process] Free PMC Article

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners. Ortega Ugalde S, de Koning CP, Wallraven K, Bruyneel B, Vermeulen NPE, Grossmann TN, Bitter W, Commandeur JNM, Vos JC. Appl Microbiol Biotechnol. 2018 Nov;102(21):9231-9242. doi: 10.1007/s00253-018-9299-4. Epub 2018 Aug 22. PMID: 30136203 [PubMed - indexed for MEDLINE] Free PMC Article

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Limonciel A, Ates G, Carta G, Wilmes A, Watzele M, Shepard PJ, VanSteenhouse HC, Seligmann B, Yeakley JM, van de Water B, Vinken M, Jennings P. Arch Toxicol. 2018 Aug;92(8):2517-2531. doi: 10.1007/s00204-018-2256-2. Epub 2018 Jul 14. PMID: 30008028 [PubMed - in process] Free PMC Article

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion. Huseinovic A, Dekker SJ, Boogaard B, Vermeulen NPE, Kooter JM, Vos JC. Amino Acids. 2018 Oct;50(10):1377-1390. doi: 10.1007/s00726-018-2613-8. Epub 2018 Jul 5. PMID: 29978260 [PubMed - indexed for MEDLINE] Free PMC Article

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants. Luirink RA, Dekker SJ, Capoferri L, Janssen LFH, Kuiper CL, Ari ME, Vermeulen NPE, Vos JC, Commandeur JNM, Geerke DP. J Inorg Biochem. 2018 Jul;184:115-122. doi: 10.1016/j.jinorgbio.2018.04.013. Epub 2018 Apr 24. PMID: 29723739 [PubMed - in process]

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells. Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM, Vos JC. Front Pharmacol. 2018 Apr 18;9:388. doi: 10.3389/fphar.2018.00388. eCollection 2018. PMID: 29720942 [PubMed] Free PMC Article

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems. Pamies D, Bal-Price A, Chesné C, Coecke S, Dinnyes A, Eskes C, Grillari R, Gstraunthaler G, Hartung T, Jennings P, Leist M, Martin U, Passier R, Schwamborn JC, Stacey GN, Ellinger-Ziegelbauer H, Daneshian M. ALTEX. 2018;35(3):353-378. doi: 10.14573/altex.1710081. Epub 2018 Apr 13. PMID: 29697851 [PubMed - indexed for MEDLINE] Free Article

Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium. Ortega Ugalde S, Luirink RA, Geerke DP, Vermeulen NPE, Bitter W, Commandeur JNM. J Inorg Biochem. 2018 Mar;180:47-53. doi: 10.1016/j.jinorgbio.2017.12.003. Epub 2017 Dec 7. PMID: 29232638 [PubMed - indexed for MEDLINE]


2017


A snapshot on the progress of in vitro toxicology for safety assessment. Jennings P, Corvi R, Culot M. Toxicol In Vitro. 2017 Dec;45(Pt 3):269-271. doi: 10.1016/j.tiv.2017.10.024. No abstract available. PMID: 29195642 [PubMed - indexed for MEDLINE]

eTOX ALLIES: an automated pipeLine for linear interaction energy-based simulations. Capoferri L, van Dijk M, Rustenburg AS, Wassenaar TA, Kooi DP, Rifai EA, Vermeulen NPE, Geerke DP. J Cheminform. 2017 Nov 21;9(1):58. doi: 10.1186/s13321-017-0243-x. PMID: 29159598 [PubMed] Free PMC Article

Adverse outcome pathways: opportunities, limitations and open questions. Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG. Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review. PMID: 29051992 [PubMed - indexed for MEDLINE]

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop. Corvi R, Madia F, Guyton KZ, Kasper P, Rudel R, Colacci A, Kleinjans J, Jennings P. Toxicol In Vitro. 2017 Dec;45(Pt 3):278-286. doi: 10.1016/j.tiv.2017.09.010. Epub 2017 Sep 12. PMID: 28911985 [PubMed - indexed for MEDLINE] Free PMC Article

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion. Wilmes A, Rauch C, Carta G, Kern G, Meier F, Posch W, Wilflingseder D, Armstrong L, Lako M, Beilmann M, Gstraunthaler G, Jennings P. Toxicol In Vitro. 2017 Dec;45(Pt 3):445-454. doi: 10.1016/j.tiv.2017.07.023. Epub 2017 Aug 15. PMID: 28821352 [PubMed - indexed for MEDLINE]

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity. Zhang Y, den Braver-Sewradj SP, Vos JC, Vermeulen NPE, Commandeur JNM. Toxicol Lett. 2017 Jun 5;275:83-91. doi: 10.1016/j.toxlet.2017.05.003. Epub 2017 May 3. PMID: 28478157 [PubMed - indexed for MEDLINE]

Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine. Zhang Y, Vermeulen NP, Commandeur JN. Br J Clin Pharmacol. 2017 Mar;83(3):572-583. doi: 10.1111/bcp.13148. Epub 2016 Nov 16. PMID: 27718269 [PubMed - indexed for MEDLINE] Free PMC Article