Total 224 results found.
Tag: All Publications Ordering

Application of CYP102A1M11H as a Tool for the Generation of Protein Adducts of Reactive Drug Metabolites; J. S. Boerma, N. P. E. Vermeulen, and J. N. M. Commandeur; Chem. Res. Toxicol., 2011, 24 (8), pp 1263–1274; DOI: 10.1021/tx2001515

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen. Dragovic S, Venkataraman H, Begheijn S, Vermeulen NP, Commandeur JN. Toxicol Lett. 2014 Jan 13; 224(2): 272-81. doi: 10.1016/j.toxlet.2013.10.023. Epub 2013 Oct 31. Pubmed

Santos R, Hritz J, Oostenbrink C. [2009]: Role of water in molecular docking simulations of cytochrome P450 2D6. J ChemInf Model.50, 146-154.
Rydberg P, Vasanthanathan P, Oostenbrink C, Olsen L. [2009]: Fast prediction of Cytochrome P450 mediated drug metabolism. ChemMedChem.
Rupenyan A, Commandeur JNM, Groot ML [2009]: CO Photodissociation dynamics in cytochrome P450BM3 studied by sub-picosecond visible and mid-infrared spectoscop. Biochem 48, 6104-6110.

van Leeuwen J.S., Unlü B., Vermeulen N.P., Vos J.C. (2012): Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. Toxicol in Vitro, Mar:26(2):197-205.

Zoldak G, Aumüller T, Lücke C, Hritz J, Oostenbrink C, Fischer G, Schmid FX [2009]: A library of luorescent peptides for exploring the sybstrate specificities of prolyl isomerases. Biochem. 48, 10423-10436.
Vasanthanathan P., Hritz J., Taboureau O., Olsen L., Jorgensen F.S., Vermeulen N.P.E., Oostenbrink C. Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands J. Chem. Inf. Model. 49 (2009) pp: 43 - 52. Pubmed
Marucci G, Finaurini S, Buccioni M, Lammi C, Kandhavelu M, Volpini R, Ricciutelli M, Angeli P, Commandeur JN, Cristalli G. [2008]: In vitro metabolism studies of new adenosine A 2A receptor antagonists. Drug Metab Lett. 2(4): 301-7. PubMed
Appiah-Opong R., de Esch I., Commandeur J.N., Andarini M., Vermeulen N.P. Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur. J. Med. Chem. 43 (2008) pp: 1621-1631. Pubmed
Appiah-Opong R., Commandeur J.N., Axson C., Vermeulen N.P. Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. Food Chem Toxicol. 46 (2008) pp: 3598-3603. Pubmed
Bonifacio A., Millo D., Keizers P.H., Boegschoten R., Commandeur J.N., Vermeulen N.P., Gooijer C., van der Zwan G. Active-site structure, binding and redox activity of the heme-thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study. J. Biol. Inorg. Chem. 13 (2008) pp: 85-96. Pubmed
Damsten M.C., de Vlieger J.S., Niessen W.M., Irth H., Vermeulen N.P., Commandeur J.N. Trimethoprim: Novel Reactive Intermediates and Bioactivation Pathways by Cytochrome P450s. Chem. Res. Toxicol. 21 (2008) pp: 2181-2187. Pubmed
Damsten M.C., van Vugt-Lussenburg B.M., Zeldenthuis T., de Vlieger J.S., Commandeur J.N., Vermeulen N.P. Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites. Chem. Biol. Interact. 10; 171 (2008) pp: 96-107. Pubmed
Hritz J., Oostenbrink, C. Hamiltonian replica exchange molecular dynamics using soft-core interactions. J. Chem. Phys. 128 (2008) pp: 144121. Pubmed
Hritz J., de Ruiter A., Oostenbrink C. Impact of plasticity and flexibility on docking results for Cytochrome P450 2D6: a combined approach of molecular dynamics and ligand docking. J. Med. Chem. 51 (2008) pp: 7469-7477. Pubmed
Jenkins R.E., Kitteringham N.R., Goldring C.E., Dowdall S.M., Hamlett J., Lane C.S., Boerma J.S., Vermeulen N.P., Park B.K. Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. Proteomics 8 (2008) pp: 301-315. Pubmed
Kool J., van Marle A., Hulscher S., Selman M., van Iperen D.J., van Altena K., Gillard M., Bakker R.A., Irth H., Leurs R., Vermeulen N.P. A flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of cAMP production. J. Biomol. Screening. 12 (2008) pp: 1074-1083. Pubmed
Reinen J., Kool J., Vermeulen N.P. Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization. Anal. Bioanal. Chem. 390 (2008) pp: 1987-1998. Pubmed
Stjernschantz E., van Vugt-Lussenburg B.M., Bonifacio A., de Beer S.B., van der Zwan G., Gooijer C., Commandeur J.N., Vermeulen N.P., Oostenbrink C. Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3. Proteins 71 (2008) pp: 336-352. Pubmed
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