Total 224 results found.
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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Ramaiahgari S.C., den Braver M.W., Herpers B., Terpstra V., Commandeur J.N., van de Water B., Price L.S.. Arch Toxicol. 2014 May; 88(5): 1083-95. doi: 10.1007/s00204-014-1215-9. Epub 2014 Mar 6.

Biotransformation of Endocrine Disrupting Compounds by Selected Phase I and Phase II Enzymes - Formation of Estrogenic and Chemically Reactive Metabolites by Cytochromes P450 and Sulfotransferases. Reinen J., Vermeulen N.P. Curr Med Chem. 2015;22(4):500-27.


Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme. Venkataraman H., Te Poele E.M., Rosłoniec K.Z., Vermeulen N., Commandeur J.N., van der Geize R., Dijkhuizen L. Appl Microbiol Biotechnol. 2014 Dec 16. [Epub ahead of print]


Cytochrome p450-mediated bioactivation of mefenamic Acid to quinoneimine intermediates and inactivation by human glutathione s-transferases. Venkataraman H., den Braver M.W., Vermeulen N.P., Commandeur J.N. Chem Res Toxicol. 2014 Dec 15; 27(12): 2071-81. doi: 10.1021/tx500288b. Epub 2014 Nov 18.


Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Venkataraman H., Verkade-Vreeker M.C., Capoferri L., Geerke D.P., Vermeulen N.P., Commandeur J.N. Bioorg Med Chem. 2014 Oct 15; 22(20):5613-20. doi: 10.1016/j.bmc.2014.06.022. Epub 2014 Jun 19.


Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid. Vredenburg G., Elias N.S., Venkataraman H., Hendriks D.F., Vermeulen N.P., Commandeur J.N., Vos J.C. Chem Res Toxicol. 2014 Apr 21; 27(4):576-86. doi: 10.1021/tx400431k. Epub 2014 Feb 26.


A comparison between QM/MM and QM/QM based fitting of condensed-phase atomic polarizabilities. Vosmeer C.R., Kiewisch K., Keijzer K., Visscher L., Geerke D.P. Phys Chem Chem Phys. 2014 Sep 7; 16(33):17857-62. doi: 10.1039/c4cp02401j.

Towards automated binding affinity prediction using an iterative linear interaction energy approach. Vosmeer C.R., Pool R., Van Stee M.F., Peric-Hassler L., Vermeulen N.P., Geerke D.P. Int J Mol Sci. 2014 Jan 9;15(1):798-816. doi: 10.3390/ijms15010798.


Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Vredenburg G., den Braver-Sewradj S., van Vugt-Lussenburg B.M., Vermeulen N.P., Commandeur J.N., Vos J.C. Toxicol Lett. 2014 Nov 6; 232(1): 182-192. doi: 10.1016/j.toxlet.2014.11.005. [Epub ahead of print]


Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors Lange JH, Venhorst J, van Dongen MJ, Frankena J, Bassissi F, de Bruin NM, den Besten C, De Beer SB, Oostenbrink C, Markova N, Kruse CG Eur J Med Chem. 2011 oct; 46(10):4808-19
Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates. Rea V, Dragovic S, Boerma JS, de Kanter FJ, Vermeulen NP, Commandeur JN. Drug Metab Dispos. 2011 Dec;39(12):2411-20. Epub 2011 Sep 2. PMID: 21890734 [PubMed - in process] Related citations
Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space. Reinen J, van Leeuwen JS, Li Y, Sun L, Grootenhuis PD, Decker CJ, Saunders J, Vermeulen NP, Commandeur JN. Drug Metab Dispos. 2011 Sep;39(9):1568-76. Epub 2011 Jun 14. PMID: 21673132 [PubMed - in process] Related citations
Involvement of the pleiotropic drug resistance response, protein kinase C signaling, and altered zinc homeostasis in resistance of Saccharomyces cerevisiae to diclofenac. van Leeuwen JS, Vermeulen NP, Vos JC. Appl Environ Microbiol. 2011 Sep;77(17):5973-80. Epub 2011 Jul 1. PMID: 21724882 [PubMed - indexed for MEDLINE ] Related citations
Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11. Vottero E, Rea V, Lastdrager J, Honing M, Vermeulen NP, Commandeur JN. J Biol Inorg Chem. 2011 Aug;16(6):899-912. Epub 2011 May 13. PMID: 21567268 [PubMed - indexed for MEDLINE] Free PMC Article Related citations
Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates. Orhan H, Vermeulen NP. Curr Drug Metab. 2011 May;12(4):383-94. Review. PMID: 21395525 [PubMed - indexed for MEDLINE] Related citations
Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H, Dragovicc S, Vermeulen NPE, Commandeur JNM, Danen E, de Graauw M, van de Water B. Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis (2011)
de Beer SB, Glättli A, Hutzler J, Vermeulen NPE, Oostenbrink C. (2011) Molecular Dynamics Simulations and Free Energy Calculations on the Enzyme 4-Hydroxyphenylpyruvate Dioxygenase. J Comput Chem,
van Leeuwen JS, Vredenburg G, Dragovic S, Tjong TFJ, Vos JC, Vermeulen NPE (2011) Metabolism related toxicity of diclofenac in yeast as model system. Toxicl Letters, 162-168.
van Leeuwen JS, Orij R, Luttik MAH, Smits GJ, Vermeulen NPE, Vos JC. (2011) Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction. Microbiol, 157, 685-694.
Reinen J, Kalma LL, Begheijn S, Heus F, Commandeur JNM, Vermeulen NPE (2011) Application of cytochrome P450BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone. Xenobiotica, 41, 59-70.
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