Total 224 results found.
Tag: All Publications Ordering
van Lipzig M.M.H., ter Laak A.M., Jongejan A., Vermeulen N.P.E., Wamelink M., Geerke D., Meerman J.H.N. Prediction of ligand binding affinity and orientation of (xeno)estrogens to the estrogen receptor (Era) by molecular dynamics simulations and the linear interaction energy (LIE) method. J. Med. Chem. 47 (2004) pp: 1018-1030. Pubmed
Orhan H., Vermeulen N.P.E., Tump C., Zappey H., Meerman J.H.N. Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by LC-tandem mass spectrometry as non-invasive biomarkers for oxidative damage. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 799 (2004) pp: 245-254. Pubmed
van Herwijnen R., de Graaf C., Govers H.A.J., Parsons J.R. Estimation of kinetix parameter for the biotransformation of three-ring azaarenes by the phenanthrene-degrading strain sphingomonas sp.lh 128. Environm. Toxicol.and Chem. 23 (2004) pp: 331-338.
Venhorst J., ter Laak A.M., Meijer M., van de Wetering I., Commandeur J.N.M., Rooseboom M., Vermeulen N.P.E. Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase. J. Mol. Graph. Model. 22 (2003) pp: 55-70. Pubmed
Vermeulen N.P.E. Prediction of drug metabolism: the case of cytochrome P450 2D6. Curr. Top. Med. Chem. 3 (2003) pp: 1227-1239. Pubmed
Venhorst J., Rooseboom M., Vermeulen N.P.E., Commandeur J.N.M. Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates. Xenobiotica 33 (2003) pp: 57-72. Pubmed
Venhorst J., ter Laak A.M., Commandeur J.N.M., Funae Y. , Hiroi T., Vermeulen N.P.E. Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J. Med. Chem. 46 (2003) pp: 74-86. Pubmed
Vermeulen N.P.E. Stereoselective bioactivation and bioinactivation - toxicological aspects. Handbook of Experimental Pharmacology, Eds M. Eichelbaum, B. Testa and H. Somogyi, Springer Verlag GmbH, Heidelberg (2003) pp: 227-248.
van der Oost R., Beyer J., Vermeulen N.P.E. Fish biomarkers and environmental risk assessment: a review. Environm. Pharmacol. Toxicol. 13 (2003) pp: 59-149.
van Gijssel H.E., Mullenders L.H.F., van Oosterwijk M.F., Meerman J.H.N. Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorenene DNA-adducts. Life Sciences 73 (2003) pp: 1759-1771. Pubmed
Rooseboom M., Vermeulen N.P.E., Durgut F.,Commandeur J.N.M. Comparative study on the bioactivation mechanisms and cytotoxicity of S-phenyl-L-cysteine. Chem. Res. Toxicol. 15 (2002) pp: 1610-1618. Pubmed
Rooseboom M., Vermeulen N.P.E., Groot E.J., Commandeur J.N.M. Tissue distribution of cytosolic beta-elimination reactions o selenocysteine Se-conjugates in rat and human. Chem. Biol. Interact. 140 (2002) pp: 243-264. Pubmed
't Hoen P.A.C., Out R., Commandeur J.N.M., Vermeulen N.P.E., van Batenburg F.H., Manoharan M., van Berkel T.J., Biessen E.A., Bijsterbosch M.K. Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu. RNA 8 (2002) pp: 1572-1583. Pubmed
't Hoen P.A.C., Rooseboom M., Bijsterbosch M.K., van Berkel T.J.C., Vermeulen N.P.E., Commandeur J.N.M. Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates. Biochem. Pharmacol. 63 (2002) pp:1843-1849. Pubmed
't Hoen P.A.C., Rosema B.S., Commandeur J.N.M., Vermeulen N.P.E., Manoharan M., van Berkel T.J.C., Biessen E.A.L., Bijsterbosch M.K. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. Eur. J. Biochem. 269 (2002) pp: 2574-2583. Pubmed
Rooseboom M., Schaaf G., Commandeur J.N.M., Vermeulen N.P.E., Fink-Gremmels J. Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines. J. Pharmacol. Exp. Ther. 301 (2002) pp: 884-892. Pubmed
Rooseboom M., Vermeulen N.P.E., Commandeur J.N.M. Enzymatic pathways of beta - elimination of chemopreventive selenocysteine Se - conjugates. Methods in Enzymol. 348 (2002) pp: 191-200. Pubmed
ter Laak A.M., de Groot M.J., Vermeulen N.P.E. Molecular modeling approaches to predicting drug metabolism and toxicity. Drug-drug interactions (2002) pp: 505.
Rooseboom M., Vermeulen N.P.E., Durgut F., Commandeur J.N.M. Synthesis, metabolism and toxicity of Te-Phenyl-L-Tellurocysteine, a novel organotellurium compound - a comparison with its sulfur and selenium analogs. Chem. Res. Toxicol. 15 (2002) pp: 1610-1618.
Murk A.J., Legler J., van Lipzig M.M.H., Meerman J.H.N., Belfroid A.C., Spenkelink A., van der Burg B., Rijs G.B., Vethaak D. Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays. Environm. Toxicol. Chem. 21 (2002) pp: 16-23. Pubmed
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