Total 224 results found.
Tag: All Publications Ordering
Zhou Y., Oostenbrink C., van Gunsteren W.F., Hagen W.R., de Leeuw S.R., Jongejan J. Relative stability of homochiral and heterochiral dialanine peptides. Effects of perturbation pathways and force-field parameters on free energy calculations. Mol. Phys. 104 (2005) pp: 1961 - 1969
Soares T.A.,. Hünenberger P.H., Kastenholz M.A., Kräutler V., Lenz T., Lins R.D., Oostenbrink C., van Gunsteren W.F. An improved nucleic-acid parameter set for the GROMOS force field. J. Comput. Chem. 26 (2005) pp: 725 - 737. Pubmed
Orhan H., Coolen S., Meerman J.H.N. Quantification of urinary o,o'-dityrosine, a biomarker for oxidative damage to proteins, by high performance liquid chromatography with triple quadrupole tandem mass spectrometry. A comparison with ion-trap tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 827 (2005) pp: 104-108. Pubmed
Jongejan A., de Graaf C., Vermeulen N.P.E., Leurs R., de Esch I.J.P. The role and application of in silico docking in chemical genomic research. Methods Mol. Bio. 310 (2005) pp: 63-91. Pubmed
Keizers P.H.J., Schraven L.H., de Graaf C., Hidestrand M., Ingelman-Sundberg M., van Dijk B.R., Vermeulen N.P.E., Commandeur J.N.M. Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6. Biochem. Biophys. Res. Commun. 338 (2005) pp: 1065-1074. Pubmed
Keizers P.H.J., de Graaf C., de Kanter F.J.J., Oostenbrink C., Feenstra K.A., Commandeur J.N.M., Vermeulen N.P.E. Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylampetanines in silico predictions and experimental validation. J. Med. Chem. 48 (2005) pp: 6117-6127. Pubmed
Lussenburg B.M.A., Keizers P.H.J., de Graaf C., Hidestrand M., Ingelman-Sundberg M., Vermeulen N.P.E., Commandeur J.N.M. The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent. Biochem. Pharmacol. 70 (2005) pp: 1253-1261. Pubmed
Kool J., van Liempd S.M., Ramautar R., Schenk T., Meerman J.H.N., Irth H., Commandeur J.N.M., Vermeulen N.P.E. Development of a novel cytochrome P450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography. J. Biomol. Screening 10 (2005) pp: 427-436. Pubmed
van Liempd S.M., Kool J. , Reinen J., Schenk T., Meerman J.H.N., Irth H., Vermeulen N.P.E. Development and validation of a microsomal online cytochrome P450 bioreactor to solid-phase extraction and reversed-phase liquid chromatography. J. of Chromatography 1075 (2005) pp: 205-212. Pubmed
Lussenburg B.M.A., Babel L.C., Vermeulen N.P.E., Commandeur J.N.M. Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants. Anal. Biochem. 341 (2005) pp: 148-155. Pubmed
de Graaf C., Vermeulen N.P.E., Feenstra K.A. Cytochrome P450 in silico: an integrative modeling approach. J. Med. Chem. 48 (2005) pp: 2725-2755. Pubmed
de Graaf C., Pospisil P., Pos W., Folkers G., Vermeulen N.P.E. Binding mode prediction of cytochrome P450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking. J. Med. Chem. 48 (2005) pp: 2308-2318. Pubmed
Orhan H., van Holland B., Krab B., Moeken J., Vermeulen N.P.E., Hollander P., Meerman J.H.N. Evaluation of a multi-parameter biomarker set for oxidative damage in man:incresed urinary excretion of lipid, protein and DNA oxidation after one hour of exercise. Free Radical. Res. 38 (2004) pp: 1269-1279. Pubmed
Keizers P.H.J., Lussenburg B.M.A., de Graaf C., Mentink L.M., Vermeulen N.P.E., Commandeur J.N.M. Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic 7-methoxy-4-(aminomethyl)-coumarin metabolism. Biochem. Pharmacol. 68 (2004) pp: 2263-2271. Pubmed
Yenes S., Commandeur J.N.M., Vermeulen N.P.E., Messeguer A. In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes. Chem. Res. Toxicol. 17 (2004) pp: 904-913. Pubmed
Orhan H., Commandeur J.N.M., Sahin A., Vermeulen N.P.E. Use of 19F-nuclear magnetic resonance and gas chromatography-electron capture detection in the quantitative analysis of fluorine-containing metabolites in urine of sevoflurane-anaesthetized patients. Xenobiotica 34 (2004) pp: 301-316. Pubmed
Oostenbrink C., Villa A., Mark A.E., van Gunsteren W.F. A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6. J. Comp. Chem. 25 (2004) pp: 1656 - 1676. Pubmed
Oostenbrink C., van Gunsteren W.F. Free energies of binding of polychlorinated biphenyls to the estrogen receptor from a single simulation. Proteins 54 (2004) pp: 234-246. Pubmed
Onderwater R.C.A., Commandeur J.N.M., Vermeulen N.P.E. Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices. Toxicol. 197 (2004) pp: 81-91. Pubmed
Rooseboom M., Commandeur J.N.M., Vermeulen N.P.E. Enzyme-catalyzed activation of anti-cancer prodrugs. Pharmacol. Reviews 56 (2004) pp: 53-102. Pubmed
<< Start < Prev 1 2 3 4 5 6 7 8 9 10 Next > End >>