Total 17 results found.
Tag: 2014 Ordering

Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites. Boerma J.S., Elias N.S., Vermeulen N.P., Commandeur J.N.  J Pharm Biomed Anal. 2014 Oct 31;103C: 17-25. doi: 10.1016/j.jpba.2014.10.025. [Epub ahead of print]

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen. Dragovic S., Venkataraman H., Begheijn S., Vermeulen N.P., Commandeur J.N. Toxicol Lett. 2014 Jan 13; 224(2): 272-81. doi: 10.1016/j.toxlet.2013.10.023. Epub 2013 Oct 31.


Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis. Maiwald S., Sivapalaratnam S., Motazacker M.M., van Capelleveen J.C., Bot I., de Jager S.C., van Eck M., Jolley J., Kuiper J., Stephens J., Albers C.A., Vosmeer C.R., Kruize H., Geerke D.P., van der Wal A.C., van der Loos C.M., Kastelein J.J., Trip M.D., Ouwehand W.H., Dallinga-Thie G.M., Hovingh G.K. PLoS One. 2014 May 30; 9(5): e98289. doi: 10.1371/journal.pone.0098289. eCollection 2014.


Genetic Control and Evolution of Anthocyanin Methylation. Provenzano S., Spelt C., Hosokawa S., Nakamura N., Brugliera F., Demelis L., Geerke D.P., Schubert A., Tanaka Y., Quattrocchio F., Koes R. Plant Physiol. 2014 May 15; 165(3): 962-977. [Epub ahead of print]


A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Ramaiahgari S.C., den Braver M.W., Herpers B., Terpstra V., Commandeur J.N., van de Water B., Price L.S.. Arch Toxicol. 2014 May; 88(5): 1083-95. doi: 10.1007/s00204-014-1215-9. Epub 2014 Mar 6.

Biotransformation of Endocrine Disrupting Compounds by Selected Phase I and Phase II Enzymes - Formation of Estrogenic and Chemically Reactive Metabolites by Cytochromes P450 and Sulfotransferases. Reinen J., Vermeulen N.P. Curr Med Chem. 2015;22(4):500-27.


Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme. Venkataraman H., Te Poele E.M., Rosłoniec K.Z., Vermeulen N., Commandeur J.N., van der Geize R., Dijkhuizen L. Appl Microbiol Biotechnol. 2014 Dec 16. [Epub ahead of print]


Cytochrome p450-mediated bioactivation of mefenamic Acid to quinoneimine intermediates and inactivation by human glutathione s-transferases. Venkataraman H., den Braver M.W., Vermeulen N.P., Commandeur J.N. Chem Res Toxicol. 2014 Dec 15; 27(12): 2071-81. doi: 10.1021/tx500288b. Epub 2014 Nov 18.


Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Venkataraman H., Verkade-Vreeker M.C., Capoferri L., Geerke D.P., Vermeulen N.P., Commandeur J.N. Bioorg Med Chem. 2014 Oct 15; 22(20):5613-20. doi: 10.1016/j.bmc.2014.06.022. Epub 2014 Jun 19.


Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid. Vredenburg G., Elias N.S., Venkataraman H., Hendriks D.F., Vermeulen N.P., Commandeur J.N., Vos J.C. Chem Res Toxicol. 2014 Apr 21; 27(4):576-86. doi: 10.1021/tx400431k. Epub 2014 Feb 26.


A comparison between QM/MM and QM/QM based fitting of condensed-phase atomic polarizabilities. Vosmeer C.R., Kiewisch K., Keijzer K., Visscher L., Geerke D.P. Phys Chem Chem Phys. 2014 Sep 7; 16(33):17857-62. doi: 10.1039/c4cp02401j.

Towards automated binding affinity prediction using an iterative linear interaction energy approach. Vosmeer C.R., Pool R., Van Stee M.F., Peric-Hassler L., Vermeulen N.P., Geerke D.P. Int J Mol Sci. 2014 Jan 9;15(1):798-816. doi: 10.3390/ijms15010798.


Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Vredenburg G., den Braver-Sewradj S., van Vugt-Lussenburg B.M., Vermeulen N.P., Commandeur J.N., Vos J.C. Toxicol Lett. 2014 Nov 6; 232(1): 182-192. doi: 10.1016/j.toxlet.2014.11.005. [Epub ahead of print]


Towards automated binding affinity prediction using an iterative linear interaction energy approach. Vosmeer CR, Pool R, Van Stee MF, Peric-Hassler L, Vermeulen NP, Geerke DP. Int J Mol Sci. 2014 Jan 9;15(1):798-816. doi: 10.3390/ijms15010798. Pubmed

Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid. Vredenburg G, Elias NS, Venkataraman H, Hendriks DF, Vermeulen NP, Commandeur JN, Vos JC. Chem. Res. Toxicol. 2014 Feb 26. [Epub ahead of print]