Total 15 results found.
Tag: 2011 Ordering
Malleability and versatility of Cytochrome P450 aactive sites studied by molecular simulations Oostenbrink C, de Ruiter A, Hritz J, Vermeulen N Curr Drug Metab. 2011 dec 30
Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors Lange JH, Venhorst J, van Dongen MJ, Frankena J, Bassissi F, de Bruin NM, den Besten C, De Beer SB, Oostenbrink C, Markova N, Kruse CG Eur J Med Chem. 2011 oct; 46(10):4808-19
Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates. Rea V, Dragovic S, Boerma JS, de Kanter FJ, Vermeulen NP, Commandeur JN. Drug Metab Dispos. 2011 Dec;39(12):2411-20. Epub 2011 Sep 2. PMID: 21890734 [PubMed - in process] Related citations
Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space. Reinen J, van Leeuwen JS, Li Y, Sun L, Grootenhuis PD, Decker CJ, Saunders J, Vermeulen NP, Commandeur JN. Drug Metab Dispos. 2011 Sep;39(9):1568-76. Epub 2011 Jun 14. PMID: 21673132 [PubMed - in process] Related citations
Involvement of the pleiotropic drug resistance response, protein kinase C signaling, and altered zinc homeostasis in resistance of Saccharomyces cerevisiae to diclofenac. van Leeuwen JS, Vermeulen NP, Vos JC. Appl Environ Microbiol. 2011 Sep;77(17):5973-80. Epub 2011 Jul 1. PMID: 21724882 [PubMed - indexed for MEDLINE ] Related citations
Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11. Vottero E, Rea V, Lastdrager J, Honing M, Vermeulen NP, Commandeur JN. J Biol Inorg Chem. 2011 Aug;16(6):899-912. Epub 2011 May 13. PMID: 21567268 [PubMed - indexed for MEDLINE] Free PMC Article Related citations
Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates. Orhan H, Vermeulen NP. Curr Drug Metab. 2011 May;12(4):383-94. Review. PMID: 21395525 [PubMed - indexed for MEDLINE] Related citations
Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H, Dragovicc S, Vermeulen NPE, Commandeur JNM, Danen E, de Graauw M, van de Water B. Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis (2011)
de Beer SB, Glättli A, Hutzler J, Vermeulen NPE, Oostenbrink C. (2011) Molecular Dynamics Simulations and Free Energy Calculations on the Enzyme 4-Hydroxyphenylpyruvate Dioxygenase. J Comput Chem,
van Leeuwen JS, Vredenburg G, Dragovic S, Tjong TFJ, Vos JC, Vermeulen NPE (2011) Metabolism related toxicity of diclofenac in yeast as model system. Toxicl Letters, 162-168.
van Leeuwen JS, Orij R, Luttik MAH, Smits GJ, Vermeulen NPE, Vos JC. (2011) Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction. Microbiol, 157, 685-694.
Reinen J, Kalma LL, Begheijn S, Heus F, Commandeur JNM, Vermeulen NPE (2011) Application of cytochrome P450BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone. Xenobiotica, 41, 59-70.
Reinen J, Ferman S, Vottero E, Vermeulen NPE, Commandeur JNM (2011) Application of a fluorescence-based continuous-flow Bioassay to screen for diversity of Cytochrome BM3 Mutant Libraries. J Biomol Screen, 16, 239-250.
N.E. Franke, D. Niewerth, Y.G. Assaraf, J. van Meerloo, K. Vojtekova, C.H. van Zantwijk, S. Zweegman, E.T. Chan, C.J. Kirk, D.P. Geerke, A.D. Schimmer, G.J.L. Kaspers, G. Jansen and J. Cloos "Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells" Leukemia 2011, DOI: 10.1038/leu.2011.256

Application of CYP102A1M11H as a Tool for the Generation of Protein Adducts of Reactive Drug Metabolites; J. S. Boerma, N. P. E. Vermeulen, and J. N. M. Commandeur; Chem. Res. Toxicol., 2011, 24 (8), pp 1263–1274; DOI: 10.1021/tx2001515