Total 25 results found.
Tag: 2007 Ordering
Damsten M, Commandeur JNM, Fidder A, Hulst AG, Touw D, Noort D, Vermeulen NPE. LC-Tandem MS Detection of Covalent Binding of Acetaminophen to Human Serum Albumin. Drug Metab Dispos. 2007, 35 (8), 1408-17. PubMed
Feenstra KA, Starikov EB, Urlacher VB, Commandeur JN, Vermeulen NPE. Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants. Protein Sci. 2007 Mar; 16(3): 420-31.PubMed
de Graaf C, Oostenbrink C, Keizers PH, van Vugt-Lussenburg BM, Commandeur JN, Vermeulen NPE. Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations. Eur Biophys J. 2007 Feb 27; [Epub ahead of print]. PubMed
Kool J, van Liempd SM, van Rossum H, van Elswijk DA, Irth H, Commandeur JN, Vermeulen NPE. Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography. Drug Metab Dispos. 2007 Apr; 35(4): 640-8. PubMed
Martinez-Cabot A, Morato A, Commandeur JNM, Vermeulen NPE and Messeguer A. In vitro bioactivation of Toxic Oil by human and rat liver microsomes and recombinant human Cytochromes P450. Chem. Res. Toxicol, 2007, 20, 1218-24.

K. Anton Feenstra†, Chris de Graaf† and Nico P.E. Vermeulen. Cytochrome P450 Protein Modeling and Ligand Docking. In: Drug-drug Interactions, Editor: D. Rodrigues, Marcel Dekker Inc. New York, 2007, in press.

Kool J., van Marle A., Hulscher S., Selman M., van Iperen D.J., van Altena K., Gillard M., Bakker R.A., Irth H., Leurs R., Vermeulen N.P.E. A Flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of c-AMP production. J. Biomol. Screen 12 (2007) pp: 1074-1083. Pubmed
Martinez-Cabot A., Morató A., Commandeur J.N.M., Vermeulen N.P.E., Messeguer A. In vitro bioactivation of 3-(N-Phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome. Chem. Res. Toxicol, 20 (2007) pp: 1218-1224. Pubmed
Stjernschantz E., van Vugt-Lussenburg B.M., Bonifacio A., de Beer S.B., van der Zwan G., Gooijer C., Commandeur J.N.M., Vermeulen N.P.E., Oostenbrink C. Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3. Proteins 71 (2007) pp: 336-352. Pubmed
Van Gunsteren W.F., Geerke D.P., Trzesniak D., Oostenbrink C., van der Vegt N.F. Analysis of the driving forces for biomolecular solvation and association. Proc. Italian School of Physics "Enrico Fermi", Course CLXV, R.A. Broglia, L. Serrano and G. Tiana (Eds.), IOS Press Amsterdam - SIF, Bologna (2007) pp: 177 – 191.
Kool J., Eggink M., van Rossum H, van Liempd S.M., van Elswijk D.A., Irth H., Commandeur J.N.M., Meerman J.H., Vermeulen N.P.E. Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures. J. Biomol. Screen. 12 (2007) pp: 396-405. Pubmed
van Vugt-Lussenburg B.M.A., Stjernschantz E., Lastdrager J., Oostenbrink C., Vermeulen, N.P.E., Commandeur J.N.M. Identification of critical residues in novel drug metabolizing mutants of Cytochrome P450 BM3 using random mutagenesis. J. Med. Chem. 50 (2007) pp: 455 – 461. Pubmed
Keller B., Christen M., Oostenbrink C., van Gunsteren W.F. On using oscillating time-dependent restraints in MD simulation. J. Biomol. NMR 37 (2007) pp: 1 – 14. Pubmed
de Graaf C., Oostenbrink C., Keizers P., van Vugt-Lussenburg B.M.A., van Waterschoot R., Tschirret-Guth R., Commandeur J.N.M., Vermeulen N.P.E Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6. Curr. Drug. Metab. 8 (2007) pp: 59 – 77. Pubmed
Feenstra K.A., Starikov E.B., Urlacher V.B., Commandeur J.N.M., Vermeulen N.P.E. Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants. Protein Sci. 16 (2007) pp: 420-431. Pubmed
Bonifacio A., Keizers P.H.J., Vermeulen N.P.E., Commandeur J.N.M., Gooijer C., van der Zwan G. Surface-enhanced resonance Raman scattering of cytochrome P450-2D6 on coated silver hydrosols. Langmuir 23 (2007) pp: 1860-1866. Pubmed
Kool J., van Liempd S.M., van Rossum H., van Elswijk D.A., Irth H., Commandeur J.N.M., Vermeulen N.P.E. Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography. Drug Metab. Dispos. 35 (2007) pp: 640-648. Pubmed
Appiah-Opong R., Commandeur J.N.M., van Vugt-Lussenburg B.M.A., Vermeulen N.P.E Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 235 (2007) pp: 83-91. Pubmed
Van Liempd S.M., Kool J., Meerman J.H.N., Irth H., Vermeulen N.P.E. Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening. Chem. Res. Toxicol. 20 (2007) pp: 1825-32. Pubmed
Bonifacio A., Groenhof A.R., Keizers P.H.J., de Graaf C., Commandeur J.N.M., Vermeulen N.P.E., Ehlers A.W., Lammertsma K., Gooijer C., van der Zwan G. Altered spin state equilibrium in the T309V mutant of Cytochrome P450 2D6: A spectroscopic and computational study. J. Biolog. Inorg. Chem. 12 (2007) pp: 645-654. Pubmed
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