VU UNIVERSITY AMSTERDAM
LOOKING FURTHER
VU UNIVERSITY AMSTERDAM
LOOKING FURTHER
VU UNIVERSITY AMSTERDAM
LOOKING FURTHER
Division of Molecular and Computational Toxicology is specialized in developing strategies for the understanding of the molecular mechanisms of chemical induced toxicity in order to better predict chemical safety in human populations. The primary focus tissues are the liver and kidney.
The research combines and integrates three main tracks:
(1) Phase I and phase II metabolism and transport (phase III), including the influences of polymorphisms,
(2) Molecular mechanisms of chemical inducedperturbations and cellular adaptions thereof.
(3) Computational methods for metabolism prediction and data integration.
The laboratory is specialized in analytical chemistry, cell culture, toxicity determination and omic analysis. In vitro models include human primary cells, human cell lines and iinduced Pluripotent Stem Cell derived cells. The group is a partner in several EU level projects on drug and chemical safety, including EUToxRisk , OpenRiskNet and the recently completed IMI projects StemBANCC and MIP-DILI.
Some of the MolTox team, February 2019. Location O2 Building, Amsterdam. From Left to Right, Chris Vos, Liliana Capinha, Jan Commandeur, Anja Wilmes, Arthur Choy, Paul Jennings, Cormac Murphy, Floor Dohmen, Tamara Meijer, Eko Rifai, Koen Visscher, Sandra Uglade, Giada Carta, Ruthmila Paskel, Jessica Moser and Ellen Langemeijer.