VU UNIVERSITY AMSTERDAM
LOOKING FURTHER
VU UNIVERSITY AMSTERDAM
LOOKING FURTHER
VU UNIVERSITY AMSTERDAM
LOOKING FURTHER
Division of Molecular and Computational Toxicology
Division of Molecular and Computational Toxicology is specialised in developing strategies for the understanding and prediction of kinetics and safety of chemicals (including pharmaceuticals) and nanoparticles. The primary focus tissues are the liver and kidney. The research combines and integrates several tracks:
(1) experimental approaches for phase I and phase II metabolism prediction including the influences of polymorphisms, (2) computational methods for metabolism prediction and (3) in vitro experimental approaches focusing on molecular mechanisms of chemical induced perturbations and associated stress. Activities also include defining and verifying adverse outcome pathways (AOPs) and development and deployment of software solutions to manage advanced in silico workflows.
The laboratory is a specialised in analytical chemistry, cell culture, toxicity determination and omic analysis. The group is a partner in several EU level projects on drug and chemical safety including EUToxRisk, OpenRiskNet, in3 and the recently finished IMI projects StemBANCC and MIP-DILI.